The Brain's Middle Crisis: What a New Study Reveals About Aging and Alzheimer's Recent research suggests that the human brain undergoes significant changes between the ages of 50 and 75.
A study published in Science reveals that this period is marked by a decline in microglia, the immune cells responsible for maintaining brain homeostasis, and their replacement with inflammatory cells.
The New York Genome Center conducted the research using advanced single cell methods to examine gene regulation and three dimensional genome organization in individual cells from the human hippocampus.